Two drivers were taken to hospital with serious injuries after a head-on collision at the intersection of Southern Cross Drive and Kingsford Smith Drive on Sunday.

About 3.30pm, police and emergency services responded to a head-on collision between a black Audi A4 and a black Hyundai Elantra.

Police believe one of the vehicles entered the intersection against a red traffic light.

Anyone with information or dashcam footage should call 1800 333000, or via the Crime Stoppers ACT website.