NSW police have issued more than 400 speeding fines and $2 million worth of tobacco and vapes were seized in a major police road safety blitz this week.

Operation Furious ran between Monday and Thursday targeting speeding and dangerous driving along the Hume Highway from the inner-city suburbs of Sydney through to Albury.

During the Operation, police issued 726 traffic infringement notices, which included 437 infringements for speeding.

Police conducted 1556 random breath testing with two positive results detected, while 370 random drug tests were performed with 12 positive results detected.

Sixteen criminal and 38 traffic charges were laid, with 10 vehicles issued with defect notices.

Police conducted 28 searches of people and vehicles, with more than $932,000 cash located and more than $2 million worth of tobacco and vapes seized.