Police hold serious concerns for the welfare missing Cristy Holder.

The 40-year-old is known to frequent Queanbeyan, and is believed to have been in the vicinity of Fyshwick, on Friday night.

She was last spoken to at about 5pm on Friday. NSW Police say that when she could not be contacted or located, officers attached to Monaro Police District started inquiries into her whereabouts.

Cristy is described as being of Caucasian appearance, about 165cm tall with heavy build and blonde hair.

Anyone with information into her whereabouts should call police or Crime Stoppers on 1800 333000.